Chris Brown

Cardiovascular development

Stem cell differentiation

Development and regulation of endothelial cell populations

Transforming growth factor Beta signal transduction

Semaphorin Signal transduction

AACP (American Association of Colleges of Pharmacy)

Chen J, Ryzhova LM, Sewell-Loftin MK, Brown CB, Huppert SS, Baldwin HS, Merryman WD. Notch1 mutation leads to valvular calcification through enhanced myofibroblast mechanotransduction. Arterioscler Thromb Vasc Biol. 2015 May 28

Hill CR, Jacobs BH, Brown CB, Barnett JV, Goudy SL. Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev. Dyn. 2015 Feb:244(2): 122-123.

Sewell-Lofton MK, Delaughter DM, Peacock JR, Brown CB, Baldwin HS, Barnett, JV, Merryman WD. Myocardial contraction and hyaluronic acid mechanotransduction in epithelial-to-mesenchymal transformation of endocardial cells. Biomaterials. 2014 Mar; 35(9) 2809-15.

Sewell-Loftin, M.K., Brown, C.B., Baldwin, H.S., Merryman, D.W. Novel technique for quantifying mouse heart valve leaflet stiffness with atomic force microscopy. J. Valv. Dis. 2012 Jul;21(4):513-20.

Hill CR, Sanchez NS, Love JD, Arieta JH, Hong CC, Brown CB, Austin AF, Barnett JV. BMP2 signals loss of epithelial character in epicardial cels but requires the Type III TgfB receptor to promote invasion. Cell Signal. 2012 May;24(5):1012-22.

Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert S, Baldwin HS, Goudy S. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum. Mol. Genetics. 2011 21(6), 1374-1383.

Sánchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV. The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Dev Biol. 2011 Oct 15;358(2):331-343.

Angel PM, Nusinow D, Brown CB, Violette K, Barnett JV, Zhang B, Baldwin HS, Caprioli RM. Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves. J Proteome Res. 10(2):812-23. 2011

Nie X, Brown CB, Wang Q, Jiao K. Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling. Cells Tissues Organs. 193(6):393-403. 2011.

Goudy, S., Law, A. Sanchez, G, Baldwin HS. and Brown, C.B. Tbx1 is Necessary for Palatal Elongation and Elevation. Mech Dev.127(5-6):292-300. 2010

Levin, M.D., Lu, M-M, Petrenko, N.B., Hawkins, B.J., Gupta, T.H., Lang, D., Buckley, P.T., Jochems, J.J., Liu, F., Spurney, C.F., Yuan, l.J., Jacobson, J.T., Brown, C.B., Huang, L., Beermann, F., Margulies, K.B., Muniswamy, M., Eberwine, J.H., Epstein, J.A., Patel, V.V. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. JCI, 119(11) 3420-3436. 2009

Austin, A.F., Compton, L.A., Love, J.D., Brown, C.B. and Barnett, J.V. Primary and Immortalized Mouse Epicardial Cells Undergo Differentiation in Response to TgfB. Dev. Dyn. 237:366-376 , 2008.

Porras, D., Brown, C.B. Temporal-Spatial Ablation of Neural Crest in the Mouse Results in Cardiovascular Defects. Developmental Dynamics. 237:153-162, 2008

1R01 HL118386-01 Baldwin (PI) 6/01/2013- 12/31/2016
NIH / NHLBI
"TIE TEK Modulation of Cardiac Development"
The goal of this project is to understand how the receptor tyrosine kinases Tie and Tek regulate endocardial growth and cardiovascular development.
Role: Co-Investigator

1R01 HL-115103-01A1 Merryman (PI) 07/01/2013-12/31/2016
NIH/ NHLBI
"Serotonergic Receptor Targeted Therapy for Degenerative Aortic Valve Disease"
The goal of this project is to understand how serotonergic signaling through the 5HT-2B receptor mediates the dysmorphology and calcification of the aortic valve during development and disease.
Role: Co-Investigator

1U01 HL100398-01 Hatzopoulos (PI) 9/30/2009 - 6/30/2016
NIH / NHLBI
"Optimizing Cardiovascular Stem Cells for Cardiac Repair and Regeneration"
Role: Co-Investigator

NIH P30 ES000267 04/01/2012 - 03/31/2013
Center in Molecular Toxicology Pilot Project
" NFATc1, a Potential Mediator of TCDD Induced Developmental Vascular Defects"
Role: Co-Investigator
U54 RR 024358 Maas (PI) 09/30/2007-06/30/2012
NIH [1RL1 HL092551]

"Syscode:Systems based Consortium of Organ Design and Engineering"
Multi-institutional (Harvard, MIT, Vanderbilt) program for organ design
Project 3 "Heart Valve Design and Engineering"
Role: Collaborator

R01 HL085708 Barnett, (PI) 02/01/2008-01/31/2012
NIH/NHLBI
"Type III transforming growth factor beta receptor in coronary vessel development"
Role of growth factor signaling in coronary development
Role: Co-Investigator

5P30 DK079341-02 Harris (PI) 09/01/2008 - 08/30/2013
NIH / NIDDK
Vanderbilt O'Brien Mouse Kidney Physiology and Disease Center
“Modulation of renal ischemia reperfusion injury by NFAT
Role: Co-Investigator

5R01 HL086964-02 Baldwin (PI) 07/01/2008 - 5/31/2012 NIH / NHLBI
"The Role of NDRG4 in Myocardial Development"
Role: Co-Investigator

Predoctoral fellowship Mundell 07/01/2006-6/30/2008
American Heart Association
"Semaphorin Regulation of Cardiac Neural Crest Development"
"To determine the mechanism of Semaphorin 3C Regulation of Cardiac Neural Crest Cell Function."
Role: Pre-doctoral sponsor

F32 HL082101 Diego Porras MD 07/19/2005-7/18/2007
NIH/NHLBI (NRSA)
"The Secondary Heart Field in Outflow Tract Remodeling"
To determine the contribution of Tbx1 expressing cells to outflow tract development and remodeling.
Role: Post-doctoral sponsor

Scientist Development Grant(0430085N) 1/01/2004-12/31/2007
American Heart Association
"Tbx1 Regulation of Cardiovascular Development and Morphogenesis"
To determine the cell-autonomous and cell non-autonomous functions of Tbx1 in patterning and morphogenesis of the cardiovascular system.
Role: PI

Basil O'Connor Starter Scholar Research Award 02/01/2005-12/31/07
March of Dimes Birth Defects Foundation
"Semaphorin 3C Signaling in Cardiac Neural Crest Development"
"To determine the role of Semaphorin 3C signaling in the cardiac neural crest during pharyngeal arch and conotruncal patterning in the mouse."
Role:PI

F32 AR08584-03 Brown (PI) 02/01/2000-1/31/2003
NIH/NIAMS NRSA
"Somite specific expression of Pax3 in transgenic mice."
"To determine the molecular regulation of Pax3 expression in the somite and muscle precursors."
Role: PI